AUTHOR=Ding Jiayue , Liu Yu , Li Xiangyu , Chen Zhiying , Guan Jingwei , Jin Kexin , Wang Zhongao , Ding Yuchuan , Ji Xunming , Meng Ran 

TITLE=Normobaric Oxygen May Ameliorate Cerebral Venous Outflow Disturbance-Related Neurological Symptoms

JOURNAL=Frontiers in Neurology

VOLUME=Volume 11 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.599985

DOI=10.3389/fneur.2020.599985

ISSN=1664-2295

ABSTRACT=Cerebral venous outflow disturbance (CVOD) has begun to garner the attention of researches owing to a series of clinical symptoms that impose a significant impact on people’s quality of life. Herein, we aimed to investigate whether normobaric oxygen (NBO) can ameliorate CVOD-induced neurological symptoms. This was one part of the prospective trial registered in ClinicalTrial.gov (NCT03373292). A total of 37 CVOD patients were divided into the NBO group (5-8L/min of oxygen inhalation, 1 hour per time, 3 times daily, n=19) and the control group (without oxygen inhalation, n=18) randomly. The assessments were performed at admission, 1-week hospitalization and 6-month follow-up. Quantitative electroencephalogram (qEEG) data were recorded prior to and post 1-hour of NBO in some patients. R software was used for data analysis. No NBO-related adverse events were observed during the whole NBO intervention process. The 1-week Patient Global Impression of Change (PGIC) scale showed that the symptoms improvement occurred in 9 patients in the NBO group (47.4%), while none in the control group (p=0.001). The NBO could improve headache evaluated with visual analogue scale (Pre-NBO vs. Post-NBO: 4.70±2.16 vs. 2.90±2.03, p=0.024) and headache impact test-6 (53.40±12.15 vs. 50.30±13.04, p=0.041). As for 6-month PGIC follow-up, 8 out of 14 cases (57.1%) in the NBO group reported improvement, while only one out of 12 patients in the control group replied mild improvement (p=0.014). The qEEG revealed that NBO reduced the ratio of theta to alpha power (0.65±0.38 vs. 0.56±0.35, p=0.030) over the fronto-central electrodes. To sum up, NBO may be a safe and effective approach to attenuate CVOD-related symptoms (especially for headache) by brain functional improvement resulting from increasing oxygen supply to brain tissues.