AUTHOR=Paredes-Aragón Elma M. , Valdéz-Ruvalcaba Héctor E. , Santos-Peyret Andrea , Cisneros-Otero Marcela , Medina-Rioja Raúl , Orozco-Suárez Sandra , Hernandez Miriam M. , Breda-Yepes Michele D. L. , Rivas-Alonso Verónica , Flores-Rivera José J. , Martínez-Juárez Iris E. 

TITLE=Continuous Visual Focal Status Epilepticus as the Primary Presentation of NMDA-R and GAD65-R Autoimmune Epilepsy

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.598974

DOI=10.3389/fneur.2020.598974

ISSN=1664-2295

ABSTRACT=<p><italic>Epilepsia partialis continua (EPC</italic>) has changed in its clinical and pathophysiological definition throughout time. Several etiologies have been described in addition to classic causes of EPC. The following case depicts a young woman who had a peculiar onset of epilepsy with a continuous visual aura becoming a form of chronic recurrent and non-progressive EPC. The patient was initially misdiagnosed as a non-neurological entity (assumed psychiatric in origin), but finally, an immune-mediated epilepsy was diagnosed, and EEG showed focal status epilepticus during evolution. Once the diagnosis was achieved and immune treatment was established, the patient is seizure free. Early identification of an immune basis in patients with epilepsy is important because immunotherapy can reverse the epileptogenic process and reduce the risk of chronic epilepsy. To date, this is the only case reported with EPC manifesting as a continuous visual aura associated with antiglutamic acid decarboxylase 65 (anti-GAD65) and anti-<italic>N</italic>-methyl-d-aspartate (anti-NMDA) antibodies.</p>