AUTHOR=Zhou Xin-Yue , Liu Feng-Tao , Chen Chen , Luo Su-Shan , Zhao Jue , Tang Yi-Lin , Shen Bo , Yu Wen-Bo , Zuo Chuan-Tao , Wu Jian-Jun , Ding Zheng-Tong , Wang Jian , Sun Yi-Min 

TITLE=Quality of Life in Newly Diagnosed Patients With Parkin-Related Parkinson's Disease

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.580910

DOI=10.3389/fneur.2020.580910

ISSN=1664-2295

ABSTRACT=<p><bold>Introduction:</bold> Mutations in the <italic>Parkin</italic> gene are the most common cause of autosomal recessive early-onset Parkinson's disease (PD). However, little is known about the quality of life (QoL) in <italic>Parkin</italic>-related PD. Here, we investigated the patterns of QoL in newly diagnosed <italic>Parkin</italic>-related PD patients.</p><p><bold>Methods:</bold> Newly diagnosed PD patients (diagnosis made within 12 months) who had an age of onset (AOO) below 40 and underwent a PD-related genetic testing, were recruited (<italic>n</italic> = 148). Among them, 24 patients carried bi-allelic variants in <italic>Parkin</italic> (PD-<italic>Parkin</italic>) and 24 patients did not have any known causative PD mutations, or risk variants (GU-EOPD). The clinical materials, relevant factors and determinants of QoL were analyzed.</p><p><bold>Results:</bold> PD-<italic>Parkin</italic> patients had a younger AOO (<italic>p</italic> = 0.003) and longer disease duration (<italic>p</italic> = 0.005). After adjustment for AOO and disease duration, more dystonia (<italic>p</italic> = 0.034), and worse scores of non-motor symptoms including Beck depression inventory (BDI, <italic>p</italic> = 0.035), Epworth sleepiness scale (ESS, <italic>p</italic> = 0.044), and subdomains of depression/anxiety (<italic>p</italic> = 0.015) and sleep disorders (<italic>p</italic> = 0.005) in Non-motor symptoms questionnaire, were found in PD-<italic>Parkin</italic> comparing with GU-EOPD. PD-<italic>Parkin</italic> patients had poorer QoL (adjusted <italic>p</italic> = 0.045), especially in the mobility (adjusted <italic>p</italic> = 0.025), emotional well-being (adjusted <italic>p</italic> = 0.015) and bodily discomfort dimensions (adjusted <italic>p</italic> = 0.016). BDI scores (<italic>p</italic> = 0.005) and ESS scores (<italic>p</italic> = 0.047) were significant determinants of QoL in <italic>PD-Parkin</italic>.</p><p><bold>Conclusion:</bold> Newly diagnosed PD-<italic>Parkin</italic> patients showed worse QoL. More depression and excessive daytime sleepiness predicted worse QoL. For clinicians, management of depression and excessive daytime sleepiness is suggested to better improve QoL in patients with <italic>Parkin</italic> mutations.</p>