AUTHOR=Qin Hongyun , Zhu Binggen , Hu Chengping , Zhao Xudong 

TITLE=Later-Onset Hypertension Is Associated With Higher Risk of Dementia in Mild Cognitive Impairment

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.557977

DOI=10.3389/fneur.2020.557977

ISSN=1664-2295

ABSTRACT=<p>To investigate the correlation between hypertension development and the progression of mild cognitive impairment (MCI) to dementia in middle-aged and elderly people. A population-based longitudinal cognition survey of people aged 55+ was conducted. The hypertension onset age was estimated by self-reported information and medical insurance card records. To study the effect of later-onset hypertension on dementia, the incidence of dementia was compared between the two groups. Of 277 hypertensive MCI participants without dementia, 56 (20.22%) progressed to dementia (MCIp) over the 6-year follow-up. The proportion of MCIp participants in the old-age-onset hypertension group (≥65 years) was higher than that in the middle-age-onset hypertension group (27.0 vs. 15.4%, respectively; <italic>X</italic><sup>2</sup> = 5.538, <italic>P</italic> = 0.019). In the old-age-onset hypertension group, the proportion of MCIp without diabetes mellitus was higher than those with diabetes mellitus (24.7 vs. 12.6%, respectively; <italic>X</italic><sup>2</sup> = 5.321, <italic>P</italic> = 0.021) and those with increased pulse pressure was higher than those without increased pulse pressure (33.3 vs. 15.4%, respectively; <italic>X</italic><sup>2</sup> = 3.902, <italic>P</italic> = 0.048). However, the cox proportional hazard showed that older age was the only risk factor for MCIp (HR = 0.618, <italic>p</italic> = 0.000). These results suggest that individuals with later-onset hypertension may have greater cognition decline, even with blood pressure maintained at 130/80 mmHg with antihypertensive management.</p>