AUTHOR=Wu Zhimin , Xiong Senjie , Sun Xiaochuan , Shi Quanhong , Dan Wei , Zhan Yan , Xie Yanfeng , Jiang Li 

TITLE=Effects of Apolipoprotein E Polymorphism on Cerebral Oxygen Saturation After Traumatic Brain Injury

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.539627

DOI=10.3389/fneur.2020.539627

ISSN=1664-2295

ABSTRACT=<p><bold>Objective:</bold> To investigate the effects of the apolipoprotein E gene (APOE) on the cerebral oxygen saturation of patients after traumatic brain injury (TBI).</p><p><bold>Methods:</bold> Clinical data of 114 patients with TBI and 54 normal people were collected. The APOE genotypes of all subjects were determined by quantitative fluorescent polymerase chain reaction (QF-PCR). The regional cerebral oxygen saturation (rScO<sub>2</sub>) of TBI patients and normal people were monitored by near-infrared spectroscopy (NIRS).</p><p><bold>Results:</bold> The mean rScO<sub>2</sub> of patients was (55.06 ± 7.60)% in the early stage of TBI, which was significantly lower than that of normal people (67.21 ± 7.80)% (<italic>P</italic> &lt; 0.05). Single-factor and multifactor logistic regression analyses showed APOEε4 was an independent risk factor that caused the early decline of rScO2 in TBI patients. Furthermore, in the TBI group, the rScO<sub>2</sub> of APOEε4 carriers (52.23 ± 8.02)% was significantly lower than that of non-ε4 carriers (60.33 ± 7.12)% (<italic>P</italic> &lt; 0.05). But in the normal group, no significant differences in rScO<sub>2</sub> were found between APOEε4 carriers and non-carriers.</p><p><bold>Conclusion:</bold> The rScO<sub>2</sub> may be significantly decreased after TBI, and APOEε4 may be a risk factor for decreased rScO<sub>2</sub> in the early stage of TBI.</p>