AUTHOR=Zheng Wei , Chen Lin , Chen Jian-hao , Lin Xiang , Tang Yi , Lin Xiao-juan , Wu Jing , Lin Zhao-min , Lin Jing-yuan 

TITLE=Hemichorea Associated With Non-ketotic Hyperglycemia: A Case Report and Literature Review

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.00096

DOI=10.3389/fneur.2020.00096

ISSN=1664-2295

ABSTRACT=<p><bold>Objective:</bold> To explore the clinical manifestation, diagnosis, therapy, and mechanism of hemichorea associated with non-ketotic hyperglycemia (HC-NH) so as to enhance awareness and avoid misdiagnosis or missed diagnosis of the disease.</p><p><bold>Methods:</bold> A case of HC-NH was reported and reviewed in terms of the clinical features, diagnosis and treatment.</p><p><bold>Results:</bold> Hemichorea associated with non-ketotic hyperglycemia is a rare complication of diabetes mellitus, which is commonly seen in elderly women with poorly-controlled diabetes. The condition is characterized by non-ketotic hyperglycemia, unilateral involuntary choreiform movements, and contralateral basal ganglia hyper-intensity by T1-weighted MR imaging or high density on CT scans. Blood glucose control is the basal treatment, in combination with dopamine receptor antagonists and benzodiazepine sedative, in controlling hemichorea.</p><p><bold>Conclusion:</bold> In clinical practice, the possibility of unilateral chorea should be considered for diabetic patients with poor blood glucose control.</p>