AUTHOR=Chen Si , Liu Hong , Wu Qian-qian , Xu Shu-jun , Li Wei-guo , Chen Teng , Li Chao , Ma Xiang-yu , Xu Shuo , Liu Yi-ming 

TITLE=Effect of LRRK2 G2385R Variant on Subthalamic Deep Brain Stimulation Efficacy in Parkinson's Disease in a Han Chinese Population

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.01231

DOI=10.3389/fneur.2019.01231

ISSN=1664-2295

ABSTRACT=<p>Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease (PD). The G2385R variant of <italic>LRRK2</italic> is a risk factor for PD in Han Chinese individuals. We retrospectively compared the clinical outcomes of STN-DBS surgery between PD Han Chinese <italic>G2385R</italic> variant carriers and non-carriers. Fifty-seven PD patients with bilateral STN-DBS were enrolled, including 8 G2385R+ variant carriers (G2385R+ group) and 49 non-carriers (G2385R– group). Clinical data included Unified Parkinson's Disease Rating Scale (UPDRS) parts I to IV, levodopa equivalent daily dose (LEDD), Mini-Mental State Examination Scale (MMSE) score, and Hamilton Depression Rating Scale (HAMD) score measured prior to DBS and 12 months post-DBS. DBS settings were also recorded. All PD patients benefited from STN-DBS surgery. There were no statistical differences between the two groups in terms of motor function, daily living activities, and LEDD reductions at 12 months post-DBS. The rigidity of the post-surgical G2385R+ group was significantly improved compared with that of the G2385R– group (<italic>P</italic> = <italic>0.045</italic>). Post-surgical voltage in the G2385R+ group was significantly higher than that in the G2385R– group (<italic>P</italic> = <italic>0.033</italic>). STN-DBS outcomes were not influenced by the <italic>LRRK2</italic> G2385R variant in Han Chinese patients.</p>