AUTHOR=Xia Huan , Guan Yuanlin , Zaongo Silvère D. , Xia Han , Wang Ziyu , Yan Zhongfang , Ma Ping 

TITLE=Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.01202

DOI=10.3389/fneur.2019.01202

ISSN=1664-2295

ABSTRACT=<p>Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML).</p>