AUTHOR=Yang Dongming , Zhao Deming , Ali Shah Syed Zahid , Wu Wei , Lai Mengyu , Zhang Xixi , Li Jie , Guan Zhiling , Zhao Huafen , Li Wen , Gao Hongli , Zhou Xiangmei , Yang Lifeng TITLE=The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease JOURNAL=Frontiers in Neurology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.01155 DOI=10.3389/fneur.2019.01155 ISSN=1664-2295 ABSTRACT=

It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease, depression, and multiple sclerosis. Several studies have observed that PD patients generally suffer from gastrointestinal disorders and GM dysbiosis prior to displaying motor symptoms, but the specific link between the GM and PD is not clearly understood. In this review, we aim to summarize what is known regarding the correlation between the GM and PD pathologies, including direct, and indirect evidence.