AUTHOR=Prain Kerri , Woodhall Mark , Vincent Angela , Ramanathan Sudarshini , Barnett Michael H. , Bundell Christine S. , Parratt John D. E. , Silvestrini Roger A. , Bukhari Wajih , The Australian and New Zealand NMO Collaboration , Brilot Fabienne , Waters Patrick , Broadley Simon A. TITLE=AQP4 Antibody Assay Sensitivity Comparison in the Era of the 2015 Diagnostic Criteria for NMOSD JOURNAL=Frontiers in Neurology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.01028 DOI=10.3389/fneur.2019.01028 ISSN=1664-2295 ABSTRACT=
We have compared five different assays for antibodies to aquaporin-4 in 181 cases of suspected Neuromyelitis optica spectrum disorders (NMOSD) and 253 controls to assess their relative utility. As part of a clinically-based survey of NMOSD in Australia and New Zealand, cases of suspected NMOSD were referred from 23 centers. Clinical details and magnetic imaging were reviewed and used to apply the 2015 IPND diagnostic criteria. In addition, 101 age- and sex-matched patients with multiple sclerosis were referred. Other inflammatory disease (