AUTHOR=Li Miao , Liang Huaxin , Liu Chao , Liu Hongtao , Zheng Yang , Shi Wanchao , Wang Jie 

TITLE=Risk Factors of Transient Cortical Blindness After Cerebral Angiography: A Multicenter Study

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.01005

DOI=10.3389/fneur.2019.01005

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> Although transient cortical blindness is a rare complication following cerebral angiography, identification of risk factors for the development of transient cortical blindness after cerebral angiography is an important clinical issue.</p><p><bold>Material and methods:</bold> Between January 2008 and April 2018, 5,126 patients at five high-volume medical centers who underwent cerebral angiography procedures were enrolled in this multicenter cohort study. Patient baseline characteristics and surgery-related factors were analyzed. We used multivariate logistic regression to examine factors associated with transient cortical blindness.</p><p><bold>Results:</bold> Eighteen patients (0.35%) in the total cohort of 5,126 suffered transient cortical blindness. After univariate statistical analysis, no significant differences were determined between the transient cortical blindness group and the control group regarding gender (<italic>p</italic> = 0.454), age (<italic>p</italic> = 0.872), smoking (<italic>p</italic> = 0.170), diabetes (<italic>p</italic> = 0.800), and hypertension (<italic>p</italic> = 0.100). Compared with the control group, the transient cortical blindness group weighed less (<italic>p</italic> = 0.020), and had a larger dose of contrast agent (<italic>p</italic> = 0.034) and more instances of contrast agent injected into the posterior circulation (<italic>p</italic> &lt; 0.001). Logistic regression analysis identified contrast agent dose and contrast agent injected into posterior circulation as independent predictive factors for transient cortical blindness (<italic>P</italic> &lt; 0.05).</p><p><bold>Conclusion:</bold> Larger doses off contrast agent and contrast agent injected into the posterior circulation are potential independent predictive factors for transient cortical blindness following cerebral angiography.</p>