AUTHOR=Michael Neethu , Grigoryan Mher Mahoney , Kilday Kelley , Sumbria Rachita K. , Vasilevko Vitaly , van Ryn Joanne , Cribbs David H. , Paganini-Hill Annlia , Fisher Mark J. TITLE=Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy JOURNAL=Frontiers in Neurology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00966 DOI=10.3389/fneur.2019.00966 ISSN=1664-2295 ABSTRACT=
Oral anticoagulants are a critical component of stroke prevention, but carry a risk of brain hemorrhage. These hemorrhagic complications tend to occur in elderly individuals, especially those with predisposing conditions such as cerebral amyloid angiopathy (CAA). Clinical evidence suggests that non-vitamin K antagonist oral anticoagulants are safer than traditional oral anticoagulants. We analyzed whether the anticoagulant dabigatran produces cerebral microhemorrhage (the pathological substrate of MRI-demonstrable cerebral microbleeds) or intracerebral hemorrhage in aged mice with and without hemorrhage-predisposing angiopathy. We studied aged (22 months old) Tg2576 (a model of CAA) and wild-type (WT) littermate mice. Mice received either dabigatran etexilate (DE) (Tg