AUTHOR=Harada Masaya , Miura Shiroh , Kida Hiroshi , Moritaka Taiga , Irie Ken-ichi , Kamada Takashi , Uchiyama Yusuke , Shima Sayuri , Mutoh Tatsuro , Hoshino Tomoaki , Taniwaki Takayuki TITLE=Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination JOURNAL=Frontiers in Neurology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00600 DOI=10.3389/fneur.2019.00600 ISSN=1664-2295 ABSTRACT=

We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.