AUTHOR=Horváth László , Fekete István , Molnár Márk , Válóczy Réka , Márton Sándor , Fekete Klára 

TITLE=The Outcome of Status Epilepticus and Long-Term Follow-Up

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00427

DOI=10.3389/fneur.2019.00427

ISSN=1664-2295

ABSTRACT=<p><bold>Objective:</bold> This study was to investigate the outcome of status epilepticus (SE) associated with antiepileptic therapy during SE and in follow-up period, risk factors including age, co-morbidities, pre-existing epilepsy, and etiology in the East-Hungarian region.</p><p><bold>Methods:</bold> A prospective cross-sectional database was compiled from outpatient files between 2013 and 2017. Follow-up ended on 30.06.2018.</p><p><bold>Results:</bold> One hundred and thirty five episodes (male: 68, 50.4%) were evaluated, mean age and follow-up time being 64.1 ± 13.9 years and 39.9 ± 14.2 months, respectively. Of the 89 patients with pre-existing epilepsy, 34 failed to visit the outpatient unit regularly. Case fatality rate was 25.2% and 31 patients (30.7%) died after discharge due to co-morbidities; their mean survival time was 10.44 ± 8 months. Focal, generalized and combined type epilepsies were diagnosed in 67 patients (49.6%), 47 patients (34.8%), and 21 patients (15.6%) of SE, respectively. Nine patients had non-convulsive SE (NCSE). Mean seizure-free period was 6.8 ± 6.9 months. Patients taking carbamazepine (20.9%; OR: 0.37, 95%CI: 0.16–0.82; <italic>p</italic> = 0.018), levetiracetam (27.5%; OR: 0.51, 95%CI: 0.27–0.97; <italic>p</italic> = 0.041), or valproate (11.1%; OR: 0.18, 95%CI: 0.05–0.61; <italic>p</italic> = 0.0043) were expected to achieve seizure freedom after SE. The worst outcome was linked to advanced age, etiology, new onset status epilepticus, NCSE, and focal status epilepsy.</p><p><bold>Conclusion:</bold> This study highlights the importance of regular care and patient follow-up.</p>