AUTHOR=Yang Xinglong , Yang Baiyuan , Wu Mengjun , Wang Fang , Huang Xiaodong , Li Kelu , Mao Zhiwei , Xu Zhong , Ren Hui 

TITLE=Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00091

DOI=10.3389/fneur.2019.00091

ISSN=1664-2295

ABSTRACT=<p><bold>Objective:</bold> The objective of the present study was to meta-analyze relevant literature to gain a comprehensive understanding of the potential relationship between serum uric acid levels and risk of benign paroxysmal positional vertigo (BPPV).</p><p><bold>Methods:</bold> The databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were systematically searched for observational case-control studies of the association between BPPV and serum uric acid levels published up to October 2018. Data from eligible studies were meta-analyzed using Stata 12.0.</p><p><bold>Results:</bold> A total of 12 studies were included in the analysis. There was a strong tendency for serum uric acid levels to be associated with risk of BPPV among studies conducted in China (OR 0.69, 95%CI 0.01–1.40, <italic>p</italic> = 0.053), but not among studies outside China (OR 1.07, 95%CI 1.08–3.22, <italic>p</italic> = 0.33). Across all studies, serum uric acid level was significantly higher among individuals with BPPV than among controls (OR 0.78, 95%CI 0.15–1.41, <italic>p</italic> = 0.015), yet it did not independently predict risk of the disorder (OR 1.003, 95%CI 0.995–1.012, <italic>p</italic> = 0.471).</p><p><bold>Conclusion:</bold> The available evidence suggests that BPPV is associated with elevated levels of serum uric acid, but these levels may not be an independent risk factor of BPPV.</p>