AUTHOR=Zhou Chenheng , Liu Keqin , Yan Shenqiang , Jin Ying 

TITLE=Association Between Cortical Superficial Siderosis and Dementia in Patients With Cognitive Impairment: A Meta-Analysis

JOURNAL=Frontiers in Neurology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2019.00008

DOI=10.3389/fneur.2019.00008

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> It remains unclear whether cortical superficial siderosis (cSS) is associated with dementia and its subtypes. We thus performed a meta-analysis to evaluate the relationship between dementia and cSS.</p><p><bold>Methods:</bold> We searched EMBASE, PubMed, and Web of Science for relevant studies assessing risk of dementia and prevalence of cSS in patients with cognitive impairment. Fixed-effects and random-effects models were performed.</p><p><bold>Results:</bold> Seven eligible studies including 3,218 patients with definite cognitive impairment were pooled in meta-analysis. The prevalence of cSS was 3.4%. The pooled analysis demonstrates odds ratio for cSS and dementia to be 1.60 (95% CI 1.04–2.44; <italic>p</italic> = 0.031). Subgroup analysis further indicated a significant association between cSS and Alzheimer's disease (AD) (OR = 2.01, 95% CI 1.34–3.02; <italic>p</italic> &lt; 0.001), but not non-AD dementia (OR = 0.700, 95% CI 0.435–1.128; <italic>p</italic> = 0.143).</p><p><bold>Conclusions:</bold> Our meta-analysis of available published data demonstrates an increased prevalence of dementia in the subjects with pre-existing cSS, especially for AD. These findings suggest cSS to be a candidate imaging indicator for AD. Further longitudinal research is needed to investigate the clinical relevance.</p>