AUTHOR=Zuo Meimei , Xu Yi , Zhang Xiaomin , Li Man , Jia Xiuqin , Niu Jinliang , Li Dongfang , Han Yanqing , Yang Yanhui TITLE=Aberrant Brain Regional Homogeneity and Functional Connectivity of Entorhinal Cortex in Vascular Mild Cognitive Impairment: A Resting-State Functional MRI Study JOURNAL=Frontiers in Neurology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.01177 DOI=10.3389/fneur.2018.01177 ISSN=1664-2295 ABSTRACT=
The aim of this study was to investigate changes in regional homogeneity (ReHo) and the functional connectivity of the entorhinal cortex (EC) in vascular mild cognitive impairment (VaMCI) and to evaluate the relationships between such changes and neuropsychological measures in VaMCI individuals. In all, 31 patients with VaMCI and 32 normal controls (NCs) underwent rs-fMRI. Differences in whole-brain ReHo and seed-based bilateral EC functional connectivity (EC-FC) were determined. Pearson's correlation was used to evaluate the relationships between regions with significant group differences and different neuropsychological measures. Vascular mild cognitive impairment (VaMCI) patients had lower scores in Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) and higher ones in Activity of Daily Living (ADL) (