AUTHOR=Wang Yao , Huang Kaibin , Wang Shengnan , Wang Honghao , Ji Zhong , Pan Suyue , Wu Yongming 

TITLE=Outcome Prediction by 40-Hz Steady-State Response After Large Hemispheric Infarction

JOURNAL=Frontiers in Neurology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.01093

DOI=10.3389/fneur.2018.01093

ISSN=1664-2295

ABSTRACT=<p><bold>Background and Purpose:</bold> The 40-Hz steady state response (SSR) reflects early sensory processing and has the potential to differentiate disease severity. This study aims to evaluate the predictive value of 40-Hz SSRs on the prognosis of patients with large hemispheric infarction (LHI).</p><p><bold>Methods:</bold> We conducted a retrospective study in patients with LHI admitted to the neurological intensive care unit (NICU) of Nanfang Hospital, Southern Medical University, Guangzhou, China, between June 2008 and December 2014. Forty-hertz SSRs were recorded within 72 h of onset and categorized into 3 grades. The correlation between 40-Hz SSR grading and clinical outcome was examined.</p><p><bold>Results:</bold> Of the 97 eligible participants, 41 (42.3%) died within 30 days and 68 (70.1%) exhibited a poor outcome (modified Rankin Scale of 5 and 6) at 90 days after the onset of LHI. We found that 40-Hz SSRs correlated significantly with NIHSS scores at admission and patient outcome. Moreover, Grade III 40-Hz SSR (bilateral sine waves that either disappeared or were not clearly identifiable) had a specificity of 97% and a positive predictive value of 94% in predicting 90-days poor outcome; Grade III 40-Hz SSR also had a specificity of 91% and a positive predictive value of 74% in predicting 30-days mortality.</p><p><bold>Conclusions:</bold> 40-Hz SSR could be used as a simple and specific method in predicting poor prognosis after LHI.</p>