AUTHOR=Lee Jin Soo , Lee Seong-Joon , Hong Ji Man , Choi Jin Wook , Yoo Joonsang , Hong Jeong-Ho , Kim Chang-Hyun , Kim Yong-Won , Kang Dong-Hun , Kim Yong-Sun , Hwang Yang-Ha , Sohn Sung-Il 

TITLE=Solitaire Thrombectomy for Acute Stroke Due to Intracranial Atherosclerosis-Related Occlusion: ROSE ASSIST Study

JOURNAL=Frontiers in Neurology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.01064

DOI=10.3389/fneur.2018.01064

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> Solitaire, a representative stent retriever, has shown high performance in removing embolic clots. However, its reperfusion potential in intracranial atherosclerotic stenosis (ICAS)-related occlusions has rarely been reported. In this ROSE ASSIST study, we hypothesized that Solitaire device is as effective and safe for removing <italic>in situ</italic> thrombi in ICAS-related occlusions as it is for removal of embolic occlusions.</p><p><bold>Methods:</bold> Data from ASIAN KR, an observational multicenter registry (<italic>n</italic> = 720) enrolling patients who have undergone endovascular treatment for acute cervicocephalic artery occlusions, were retrospectively reviewed. Through blinded evaluations, occlusions were classified as ICAS-related (significant fixed focal stenosis observed at the occlusion site during endovascular treatment) or embolic (no or minimal stenosis observed). Among patients treated within 720 min after stroke onset, those who undertook Solitaire thrombectomy and whose underlying etiology was ICAS-related or embolic were included. The primary endpoint was immediate successful reperfusion (modified Treatment In Cerebral Ischemia 2b−3) after Solitaire stent retrieval. The safety endpoint included intracerebral hemorrhagic transformation and subarachnoid hemorrhage. Comparative analyses were performed between embolic and ICAS-related occlusions with 2:1 propensity score matching.</p><p><bold>Results:</bold> In total, 303 patients (embolic, 228; ICAS-related, 75) were included in the analyses. As for the primary endpoint, the immediate successful reperfusion rate following Solitaire thrombectomy did not differ between the two etiologic groups after propensity score matching (73.1% embolic vs. 65.8% ICAS-related, <italic>p</italic> = 0.261). The final successful reperfusion grade was also similar in the two groups (79.3 vs. 72.0%, <italic>p</italic> = 0.219). The grades and frequencies of intracerebral hemorrhagic transformation and subarachnoid hemorrhage did not differ between groups (<italic>p</italic> = 0.134 and <italic>p</italic> = 0.269, respectively).</p><p><bold>Conclusions:</bold> The immediate reperfusion performance in terms of thrombus removal of Solitaire thrombectomy for ICAS-related occlusions was similar to that for embolic occlusions.</p>