AUTHOR=Christidi Foteini , Karavasilis Efstratios , Rentzos Michail , Kelekis Nikolaos , Evdokimidis Ioannis , Bede Peter 

TITLE=Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis

JOURNAL=Frontiers in Neurology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.01005

DOI=10.3389/fneur.2018.01005

ISSN=1664-2295

ABSTRACT=<p>Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem disorder with considerable extra-motor involvement. The neuropsychological manifestations of frontotemporal, parietal, and basal ganglia involvement in ALS have important implications for compliance with assistive devices, survival, participation in clinical trials, caregiver burden, and the management of individual care needs. Recent advances in neuroimaging have been instrumental in characterizing the biological substrate of heterogeneous cognitive and behavioral deficits in ALS. In this review we discuss the clinical and radiological aspects of cognitive and behavioral impairment in ALS focusing on the recognition, assessment, and monitoring of these symptoms.</p>