AUTHOR=Thomas Christian , Lehrich Christoph , Gross Catharina C. , Wiendl Heinz , Meuth Sven G. , Melzer Nico TITLE=Primary B Cell Lymphoma of the CNS Mimicking Anti-LGI1 Limbic Encephalitis JOURNAL=Frontiers in Neurology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00658 DOI=10.3389/fneur.2018.00658 ISSN=1664-2295 ABSTRACT=

Limbic encephalitis is a potentially paraneoplastic type of encephalitis mainly involving the limbic system. Recently, diagnostic criteria comprising clinical presentation as well as imaging, laboratory and electrophysiological findings have been established. Here, we show that incipient primary central nervous system lymphoma can closely resemble limbic encephalitis including positive testing for anti-LGI1 antibodies illustrating the need for thorough interpretation of initial laboratory and radiologic findings and tight follow-up examinations.