AUTHOR=Gugliandolo Enrico , D'Amico Ramona , Cordaro Marika , Fusco Roberta , Siracusa Rosalba , Crupi Rosalia , Impellizzeri Daniela , Cuzzocrea Salvatore , Di Paola Rosanna TITLE=Neuroprotective Effect of Artesunate in Experimental Model of Traumatic Brain Injury JOURNAL=Frontiers in Neurology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00590 DOI=10.3389/fneur.2018.00590 ISSN=1664-2295 ABSTRACT=
Traumatic brain injuries (TBI) are an important public health challenge. In addition, subsequent events at TBI can compromise the quality of life of these patients. In fact, TBI is associated with several complications for both long and short term, some evidence shows how TBI is associated with a decline in cognitive functions such as the risk of developing dementia, cerebral atrophy, and Parkinson disease. After the direct damage from TBI, a key role in TBI injury is played by the inflammatory response and oxidative stress, that contributes to tissue damage and to neurodegenerative processes, typical of secondary injury, after TBI. Given the complex series of events that are involved after TBI injury, a multitarget pharmacological approach is needed. Artesunate is a more stable derivative of its precursor artemisin, a sesquiterpene lactone obtained from a Chinese plant