AUTHOR=Long Wenyong , Yuan Jian , Liu Jingping , Liu Jinfang , Wu Ming , Chen Xin , Peng Gang , Wu Changwu , Zhang Chi , Wang Xiangyu , Zhao Wei , Liu Qing 

TITLE=Multidrug Resistant Brain Abscess Due to Acinetobacter baumannii Ventriculitis Cleared by Intraventricular and Intravenous Tigecycline Therapy: A Case Report and Review of Literature

JOURNAL=Frontiers in Neurology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00518

DOI=10.3389/fneur.2018.00518

ISSN=1664-2295

ABSTRACT=<p><bold>Objective:</bold> Ventricular infection from multidrug-resistant (MDR) <italic>Acinetobacter baumannii</italic> (<italic>A. baumannii</italic>) is one of the most severe complications of craniotomy. However, the availability of effective therapeutic options for these infections is limited. Thus, this report aims to describe the efficacy of abscess clearance by intraventricular and intravenous tigecycline therapy in managing patients with multidrug-resistant <italic>A. baumannii</italic> ventriculitis after neurosurgery. Moreover, the current literature on the use of tigecycline therapy for these life-threatening infections is reviewed and summarized, and a treatment regimen based on the available data is proposed.</p><p><bold>Methods:</bold> A patient with multidrug-resistant <italic>A. baumannii</italic> ventriculitis was admitted in our hospital and was provided with a detailed therapeutic schedule. Tigecycline treatments for multidrug-resistant <italic>A. baumannii</italic> ventriculitis that were reported in the literature were also reviewed and summarized.</p><p><bold>Results:</bold> The patient in our hospital underwent abscess clearance on a ventriculoscope and was subsequently subjected to multi-route tigecycline therapy 14 days after the start of the continuous ventricular irrigation (CVI) tigecycline and 3 days after the intraventricular (IVT) tigecycline. The signs of ventriculitis disappeared, and the Acinetobacter cerebrospinal fluid (CSF) load steadily decreased until CSF sterilization. Literature review identified seven cases of ventricular infection from multidrug-resistant <italic>A. baumannii</italic> treated with tigecycline. In the eight cases, all patients were male adults (&gt;18 years), with a mean age of 46.1 (range: 22–75) years. Meningitis/ventriculitis was secondary to neurosurgery procedures for the management of various central nervous system diseases in all cases. A good clinical outcome was achieved in all eight patients with multidrug-resistant <italic>A. baumannii</italic> meningitis/ventriculitis treated with CVI and/or IVT tigecycline, and any relevant complications were not observed.</p><p><bold>Conclusions</bold>: CVI and IVT tigecycline and IVT colistin could be considered as the first-line therapy in patients with ventricular infections from MDR/extreme drug-resistant <italic>A. baumannii</italic>. However, more studies should be conducted to confirm our observation.</p>