AUTHOR=Hextrum Shannon , Bennett Stephanie TITLE=A Critical Examination of Subgroup Analyses: The National Acute Spinal Cord Injury Studies and Beyond JOURNAL=Frontiers in Neurology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2018.00011 DOI=10.3389/fneur.2018.00011 ISSN=1664-2295 ABSTRACT=

The use of high-dose methylprednisolone for acute spinal cord injury continues to be a topic of debate. This controversy largely stems from fundamental issues in statistical interpretation of trial data, most notably subgroup analyses. The purpose of this review is to discuss important examples of improper subgroup analysis and encourage better practices in future research.