AUTHOR=Fuhrer Hannah , Reinhard Matthias , Niesen Wolf-Dirk 

TITLE=Paradigm Change? Cardiac Output Better Associates with Cerebral Perfusion than Blood Pressure in Ischemic Stroke

JOURNAL=Frontiers in Neurology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00706

DOI=10.3389/fneur.2017.00706

ISSN=1664-2295

ABSTRACT=<sec id="ST1"><title>Introduction</title><p>In patients with acute ischemic stroke, penumbral perfusion is maintained by collateral flow and so far is maintained by normal mean arterial pressure (MAP) levels. Since MAP is dependent on cardiac function, optimization of cardiac output might be a valuable hemodynamic goal in order to optimize cerebral perfusion (CP).</p></sec><sec id="ST2"><title>Methods</title><p>Cerebral perfusion was assessed by transcranial color-coded duplex and transcranial perfusion sonography in 10 patients with acute large hemispheric stroke. Time-to-peak (TTP) values of defined regions of interest (ROI) within the middle cerebral artery (MCA) territory were assessed bilaterally in addition to mean flow velocities of the MCA. <italic>Via</italic> semi-invasive advanced hemodynamic monitoring systemic hemodynamic parameters were assessed, including MAP and cardiac index (CI). Patients received sonographic follow-up after optimizing CI.</p></sec><sec id="ST3"><title>Results</title><p>TTP values of the deeply located ROIs of the non-affected as well as the affected hemisphere correlated highly significantly with CI (in affected side <italic>r</italic> = −0.827, <italic>p</italic> = 0.002; and in non-affected side <italic>r</italic> = −0.908, <italic>p</italic> &lt; 0.0001). This demonstrates dependence of CP on CI, while correlation with MAP was not detected. Neither CI nor MAP revealed significant correlation with MCA velocity.</p></sec>