AUTHOR=Yang Rui-Xin , Lei Jie , Wang Bo-Dong , Feng Da-Yun , Huang Lu , Li Yu-Qian , Li Tao , Zhu Gang , Li Chen , Lu Fang-Fang , Nie Tie-Jian , Gao Guo-Dong , Gao Li TITLE=Pretreatment with Sodium Phenylbutyrate Alleviates Cerebral Ischemia/Reperfusion Injury by Upregulating DJ-1 Protein JOURNAL=Frontiers in Neurology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2017.00256 DOI=10.3389/fneur.2017.00256 ISSN=1664-2295 ABSTRACT=
Oxidative stress and mitochondrial dysfunction play critical roles in ischemia/reperfusion (I/R) injury. DJ-1 is an endogenous antioxidant that attenuates oxidative stress and maintains mitochondrial function, likely acting as a protector of I/R injury. In the present study, we explored the protective effect of a possible DJ-1 agonist, sodium phenylbutyrate (SPB), against I/R injury by protecting mitochondrial dysfunction