AUTHOR=Bernstock Joshua D. , Budinich Craig S. , Cohen Leonardo G. , Awosika Oluwole O. 

TITLE=Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone

JOURNAL=Frontiers in Neurology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2016.00050

DOI=10.3389/fneur.2016.00050

ISSN=1664-2295

ABSTRACT=<p>Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein, we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s) and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity.</p>