AUTHOR=Hardesty Douglas A., Sanai Nader TITLE=The Value of Glioma Extent of Resection in the Modern Neurosurgical Era JOURNAL=Frontiers in Neurology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2012.00140 DOI=10.3389/fneur.2012.00140 ISSN=1664-2295 ABSTRACT=

Objective: There remains no general consensus in the neurosurgical oncology literature regarding the role of extent of glioma resection in improving patient outcome. Although the value of resection in establishing a diagnosis and alleviating mass effect is clear, there is less certainty in ascertaining the influence of extent of resection (EOR). Here, we review the recent literature to synthesize a comprehensive review of the value of extent of resection for gliomas in the modern neurosurgical era. Methods: We reviewed every major peer-reviewed clinical publication since 1990 on the role of EOR in glioma outcome. Results: Thirty-two high-grade glioma articles and 11 low-grade glioma articles were examined in terms of quality of evidence, expected EOR, and survival benefit. Conclusion: Despite limitations in the quality of data, mounting evidence suggests that more extensive surgical resection is associated with longer life expectancy for both low- and high-grade newly diagnosed gliomas.