Hakim Baazaoui ¹ Stefan Engelter ^2,3,4 Henrik Gensicke ^2,3,4 Lukas S Enz ^3,4 Marios Psychogios ^4,5 Matthias Muttke ^4,5 Patrik Michel ⁶ Davide Strambo ⁶ Alexander Salerno ⁶ Henk A Marquering ⁷ Paul J Nederkoorn ⁸ Nabila Wali ⁸ Stephanie Tanadini-Lang ⁹ Björn Menze ¹⁰ Ezequiel de la Rosa ¹⁰ Kaiyuan Yang ¹⁰ Gian Marco De Marchis ^11,4 Tolga D Dittrich ^11,4 Francesco Valletta ^11,12 Manon Germann ¹³ Carlo W. Cereda ¹⁴ João Pedro Marto ¹⁵ Lisa Herzog ¹⁶ Patrick Hirschi ¹⁷ Zsolt Kulcsar ¹⁸ Susanne Wegener ^16,19*

• ¹ University Hospital Zürich, Zurich, Switzerland
• ² University Geriatric Medicine FELIX PLATTER, Basel, Switzerland
• ³ Brain Stroke Center, Department of Neurology, University Hospital of Basel, Basel, Switzerland
• ⁴ Department of Clinical Research, University Hospital of Basel, Basel, Basel-Stadt, Switzerland
• ⁵ Division of Diagnostic and Interventional Neuroradiology, University Hospital of Basel, Basel, Switzerland
• ⁶ Stroke Center, Neurology Service, Department of Neurological Sciences, Lausanne University Hospital, Lausanne, Geneva, Switzerland
• ⁷ Radiology and Nuclear Medicine / Biomedical Engineering and Physics, Amsterdam University Medical Center, Amsterdam, Netherlands
• ⁸ Department of Neurology, Amsterdam University Medical Center, Amsterdam, Netherlands
• ⁹ Department of Radiation Oncology, University Hospital Zürich, Zurich, Zürich, Switzerland
• ¹⁰ Department of Quantitative Biomedicine, Faculty of Medicine, University of Zurich, Zurich, Zurich, Switzerland
• ¹¹ Department of Neurology and Stroke Center, Cantonal Hospital St.Gallen, St. Gallen, St. Gallen, Switzerland
• ¹² DAI di Neuroscienze, Integrated University Hospital Verona, Verona, Veneto, Italy
• ¹³ Department of Radiology, Cantonal Hospital St.Gallen, St. Gallen, St. Gallen, Switzerland
• ¹⁴ Stroke Center EOC, Neurocenter of Southern Switzerland, Lugano Regional Hospital, Lugano, Ticino, Switzerland
• ¹⁵ Department of Neurology, Hospital de Egas Moniz, Lisbon, Portugal
• ¹⁶ Department of Neurology, University Hospital Zürich, Zurich, Zürich, Switzerland
• ¹⁷ Clinical Data Platform for Research, University Hospital Zürich, Zurich, Zürich, Switzerland
• ¹⁸ Department of Neuroradiology, University Hospital Zürich, Zurich, Zürich, Switzerland
• ¹⁹ Center for Neuroscience Zurich, University of Zurich, Zürich, Zürich, Switzerland

The Multicentre Acute ischemic stroke imaGIng and Clinical data (MAGIC) repository is a collaboration established in 2024 by seven stroke centres in Europe. MAGIC consolidates clinical and radiological data from acute ischemic stroke (AIS) patients who underwent endovascular therapy, intravenous thrombolysis, a combination of both, or conservative management.Participants: All centres ensure accuracy and completeness of the data. Only patients who did not refuse use of their routine data collected during or after their hospital stay are included in the repository. Approvals or waivers are obtained from the responsible ethics committees before data exchange. A formal data transfer agreement (DTA) is signed by all contributing centres. The centres then share their data and files are stored centrally at a safe server at the University Hospital Zurich. There, patient identifiers are removed and images are algorithmically de-faced. Deidentified structured clinical data are connected to the imaging data by a new identifier. Data are made available to participating centres which have entered into a DTA for stroke research projects.Repository setup: Initially, MAGIC is set to comprise initial and first follow-up imaging of 2,500 AIS patients. Clinical data consist of a comprehensive set of patient characteristics and routine prehospital metrics, treatment and laboratory variables.Outlook: Our repository will support research by leveraging the entire range of routinely collected imaging and clinical data. This dataset reflects the current state of practice in stroke patient evaluation and management and will enable researchers to retrospectively study clinically relevant questions outside the scope of randomized controlled clinical trials. New centres are invited to join MAGIC if they meet the requirements outlined here. We aim to reach approximately 10,000 cases by 2026.