AUTHOR=Valevicius Darius , Beck Natacha , Kasper Lars , Boroday Sergiy , Bayer Johanna , Rioux Pierre , Caron Bryan , Adalat Reza , Evans Alan C. , Khalili-Mahani Najmeh TITLE=Web-based processing of physiological noise in fMRI: addition of the PhysIO toolbox to CBRAIN JOURNAL=Frontiers in Neuroinformatics VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2023.1251023 DOI=10.3389/fninf.2023.1251023 ISSN=1662-5196 ABSTRACT=

Neuroimaging research requires sophisticated tools for analyzing complex data, but efficiently leveraging these tools can be a major challenge, especially on large datasets. CBRAIN is a web-based platform designed to simplify the use and accessibility of neuroimaging research tools for large-scale, collaborative studies. In this paper, we describe how CBRAIN’s unique features and infrastructure were leveraged to integrate TAPAS PhysIO, an open-source MATLAB toolbox for physiological noise modeling in fMRI data. This case study highlights three key elements of CBRAIN’s infrastructure that enable streamlined, multimodal tool integration: a user-friendly GUI, a Brain Imaging Data Structure (BIDS) data-entry schema, and convenient in-browser visualization of results. By incorporating PhysIO into CBRAIN, we achieved significant improvements in the speed, ease of use, and scalability of physiological preprocessing. Researchers now have access to a uniform and intuitive interface for analyzing data, which facilitates remote and collaborative evaluation of results. With these improvements, CBRAIN aims to become an essential open-science tool for integrative neuroimaging research, supporting FAIR principles and enabling efficient workflows for complex analysis pipelines.