AUTHOR=Najera Ricardo A. , Mahavadi Anil K. , Khan Anas U. , Boddeti Ujwal , Del Bene Victor A. , Walker Harrison C. , Bentley J. Nicole TITLE=Alternative patterns of deep brain stimulation in neurologic and neuropsychiatric disorders JOURNAL=Frontiers in Neuroinformatics VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2023.1156818 DOI=10.3389/fninf.2023.1156818 ISSN=1662-5196 ABSTRACT=

Deep brain stimulation (DBS) is a widely used clinical therapy that modulates neuronal firing in subcortical structures, eliciting downstream network effects. Its effectiveness is determined by electrode geometry and location as well as adjustable stimulation parameters including pulse width, interstimulus interval, frequency, and amplitude. These parameters are often determined empirically during clinical or intraoperative programming and can be altered to an almost unlimited number of combinations. Conventional high-frequency stimulation uses a continuous high-frequency square-wave pulse (typically 130–160 Hz), but other stimulation patterns may prove efficacious, such as continuous or bursting theta-frequencies, variable frequencies, and coordinated reset stimulation. Here we summarize the current landscape and potential clinical applications for novel stimulation patterns.