AUTHOR=Kim Ethan H. , Howard Derek , Chen Yuxiao , Tripathy Shreejoy J. , French Leon 

TITLE=LaminaRGeneVis: A Tool to Visualize Gene Expression Across the Laminar Architecture of the Human Neocortex

JOURNAL=Frontiers in Neuroinformatics

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2022.753770

DOI=10.3389/fninf.2022.753770

ISSN=1662-5196

ABSTRACT=<p>The application of RNA sequencing has enabled the characterization of genome-wide gene expression in the human brain, including distinct layers of the neocortex. Neuroanatomically, the molecular patterns that underlie the laminar organization of the neocortex can help link structure to circuitry and function. To advance our understanding of cortical architecture, we created <italic>LaminaRGeneVis</italic>, a web application that displays across-layer cortical gene expression from multiple datasets. These datasets were collected using bulk, single-nucleus, and spatial RNA sequencing methodologies and were normalized to facilitate comparisons between datasets. The online resource performs single- and multi-gene analyses to provide figures and statistics for user-friendly assessment of laminar gene expression patterns in the adult human neocortex. The web application is available at <ext-link ext-link-type="uri" xlink:href="https://ethanhkim.shinyapps.io/laminargenevis/" xmlns:xlink="http://www.w3.org/1999/xlink">https://ethanhkim.shinyapps.io/laminargenevis/</ext-link>.</p>