AUTHOR=Ortiz Andrés , Munilla Jorge , Martínez-Ibañez Manuel , Górriz Juan M. , Ramírez Javier , Salas-Gonzalez Diego TITLE=Parkinson's Disease Detection Using Isosurfaces-Based Features and Convolutional Neural Networks JOURNAL=Frontiers in Neuroinformatics VOLUME=13 YEAR=2019 URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2019.00048 DOI=10.3389/fninf.2019.00048 ISSN=1662-5196 ABSTRACT=

Computer aided diagnosis systems based on brain imaging are an important tool to assist in the diagnosis of Parkinson's disease, whose ultimate goal is the detection by automatic recognizing of patterns that characterize the disease. In recent times Convolutional Neural Networks (CNN) have proved to be amazingly useful for that task. The drawback, however, is that 3D brain images contain a huge amount of information that leads to complex CNN architectures. When these architectures become too complex, classification performances often degrades because the limitations of the training algorithm and overfitting. Thus, this paper proposes the use of isosurfaces as a way to reduce such amount of data while keeping the most relevant information. These isosurfaces are then used to implement a classification system which uses two of the most well-known CNN architectures, LeNet and AlexNet, to classify DaTScan images with an average accuracy of 95.1% and AUC = 97%, obtaining comparable (slightly better) values to those obtained for most of the recently proposed systems. It can be concluded therefore that the computation of isosurfaces reduces the complexity of the inputs significantly, resulting in high classification accuracies with reduced computational burden.