AUTHOR=Marcoux Arnaud , Burgos Ninon , Bertrand Anne , Teichmann Marc , Routier Alexandre , Wen Junhao , Samper-González Jorge , Bottani Simona , Durrleman Stanley , Habert Marie-Odile , Colliot Olivier , for the Alzheimer's Disease Neuroimaging Initiative TITLE=An Automated Pipeline for the Analysis of PET Data on the Cortical Surface JOURNAL=Frontiers in Neuroinformatics VOLUME=12 YEAR=2018 URL=https://www.frontiersin.org/journals/neuroinformatics/articles/10.3389/fninf.2018.00094 DOI=10.3389/fninf.2018.00094 ISSN=1662-5196 ABSTRACT=

We present a fully automatic pipeline for the analysis of PET data on the cortical surface. Our pipeline combines tools from FreeSurfer and PETPVC, and consists of (i) co-registration of PET and T1-w MRI (T1) images, (ii) intensity normalization, (iii) partial volume correction, (iv) robust projection of the PET signal onto the subject's cortical surface, (v) spatial normalization to a template, and (vi) atlas statistics. We evaluated the performance of the proposed workflow by performing group comparisons and showed that the approach was able to identify the areas of hypometabolism characteristic of different dementia syndromes: Alzheimer's disease (AD) and both the semantic and logopenic variants of primary progressive aphasia. We also showed that these results were comparable to those obtained with a standard volume-based approach. We then performed individual classifications and showed that vertices can be used as features to differentiate cognitively normal and AD subjects. This pipeline is integrated into Clinica, an open-source software platform for neuroscience studies available at www.clinica.run.