AUTHOR=Uddin Md Nasir , Figley Teresa D. , Kornelsen Jennifer , Mazerolle Erin L. , Helmick Carl A. , O'Grady Christopher B. , Pirzada Salina , Patel Ronak , Carter Sean , Wong Kaihim , Essig Marco R. , Graff Lesley A. , Bolton James M. , Marriott James J. , Bernstein Charles N. , Fisk John D. , Marrie Ruth Ann , Figley Chase R. TITLE=The comorbidity and cognition in multiple sclerosis (CCOMS) neuroimaging protocol: Study rationale, MRI acquisition, and minimal image processing pipelines JOURNAL=Frontiers in Neuroimaging VOLUME=1 YEAR=2022 URL=https://www.frontiersin.org/journals/neuroimaging/articles/10.3389/fnimg.2022.970385 DOI=10.3389/fnimg.2022.970385 ISSN=2813-1193 ABSTRACT=

The Comorbidity and Cognition in Multiple Sclerosis (CCOMS) study represents a coordinated effort by a team of clinicians, neuropsychologists, and neuroimaging experts to investigate the neural basis of cognitive changes and their association with comorbidities among persons with multiple sclerosis (MS). The objectives are to determine the relationships among psychiatric (e.g., depression or anxiety) and vascular (e.g., diabetes, hypertension, etc.) comorbidities, cognitive performance, and MRI measures of brain structure and function, including changes over time. Because neuroimaging forms the basis for several investigations of specific neural correlates that will be reported in future publications, the goal of the current manuscript is to briefly review the CCOMS study design and baseline characteristics for participants enrolled in the three study cohorts (MS, psychiatric control, and healthy control), and provide a detailed description of the MRI hardware, neuroimaging acquisition parameters, and image processing pipelines for the volumetric, microstructural, functional, and perfusion MRI data.