AUTHOR=Venkateswaran Nagarajan , Sekhar Sudarshan , T.S Thiagarajan , Navalpakkam Krishnan Sharath , Kannan K Dinesh , Ramanathan Subbu , Narayanasamy Naren , Jagathrakshakan Sharan Srinivas , S. R Vignesh 

TITLE=Energetics based spike generation of a single neuron: simulation results and analysis

JOURNAL=Frontiers in Neuroenergetics

VOLUME=Volume 4 - 2012

YEAR=2012

URL=https://www.frontiersin.org/journals/neuroenergetics/articles/10.3389/fnene.2012.00002

DOI=10.3389/fnene.2012.00002

ISSN=1662-6427

ABSTRACT=Existing current based models that capture spike activity, though useful in studying information processing capabilities of neurons, fail to throw light on their internal functioning. It is imperative to develop a model that captures the spike train of a neuron as a function of its intra cellular parameters for non-invasive diagnosis of diseased neurons. This is the first ever article to present such an integrated model that quantifies the inter-dependency between spike activity and intra cellular energetics. The generated spike trains from our integrated model will throw greater light on the intra-cellular energetics than existing current models. Now, an abnormality in the spike of a diseased neuron can be linked and hence effectively analyzed at the energetics level. The spectral analysis of the generated spike trains in a time-frequency domain will help identify abnormalities in the internals of a neuron. As a case study, the parameters of our model are tuned for Alzheimer disease and its resultant spike trains are studied and presented.