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ORIGINAL RESEARCH article
Front. Neuroanat.
Volume 19 - 2025 | doi: 10.3389/fnana.2025.1495735
This article is part of the Research Topic Imaging Brain Network and Brain Energy Metabolism Impairments in Brain Disorders View all 5 articles
Age-related alterations in functional and structural networks in the brain in macaque monkeys
Provisionally accepted
Kazuya Ouchi 1,2
Shinya Yamamoto 1,3
Makoto Obara 4
Yasuko Sugase-Miyamoto 1
Tomokazu Tsurugizawa 1,2*- 1 National Institute of Advanced Industrial Science and Technology (AIST), Tsuluba, Japan
- 2 Faculty of Engineering, Information and Systems, University of Tsukuba, Tsukuba, Ibaraki, Japan
- 3 Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
- 4 Philips (Japan), Tokyo, Japan
Resting-state networks (RSNs) have been used as biomarkers of brain diseases and cognitive performance. However, age-related changes in the RSNs of macaques, a representative animal model, are still not fully understood. In this study, we measured the RSNs in macaques aged 3-20 years and investigated the age-related changes from both functional and structural perspectives. The proportion of structural connectivity in the RSNs relative to the total fibers in the whole brain significantly decreased, whereas functional connectivity showed an increasing trend with age. Additionally, the amplitude of low-frequency fluctuations tended to increase with age, indicating that resting-state neural activity may be more active in the RSNs may increase with age. These results indicate that structural and functional alterations in typical RSNs are age-dependent and can be a marker of aging in the macaque's brain.
Keywords: macaque monkey, functional connectivity, structural connectivity, network, MRI
Received: 13 Sep 2024; Accepted: 19 Feb 2025.
Copyright: © 2025 Ouchi, Yamamoto, Obara, Sugase-Miyamoto and Tsurugizawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tomokazu Tsurugizawa, National Institute of Advanced Industrial Science and Technology (AIST), Tsuluba, Japan
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