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ORIGINAL RESEARCH article

Front. Neuroanat.
Volume 18 - 2024 | doi: 10.3389/fnana.2024.1500181
This article is part of the Research Topic Editors’ Showcase: Frontiers in Neuroanatomy View all 5 articles

Ramón y Cajal´s 'lenticular tract' represents infrasubthalamic pyramidal collaterals targeting mesodiencephalic centers: an obscure misunderstood aspect of the motor pathway clarified by Allen Mouse Brain Connectivity data

Provisionally accepted
  • Departamento de Ciencias Morfológicas y Psicobiolo, University of Murcia, Murcia, Spain

The final, formatted version of the article will be published soon.

    Ramón y Cajal described repeatedly in mammals a diencephalic tegmental tract he wrongly identified as corresponding to Forel’s lenticular tract, while insisting it was formed by fasciculated infrasubthalamic collaterals of the pyramidal tract. These fibers circulated backwards between the zona incerta and the substantia nigra and were lost in the rubral neighborhood, so that their targets remained unknown. The modern literature does not register these pyramidal collaterals at all. In this report, anterograde axon-tracing experiments with motor cortex injections available at the Allen Mouse Brain Connectivity database were studied to assess whether Ramón y Cajal’s collateral tract exists in the mouse and, in that case, examine the issue of its missing targets. All Allen motor cortex experiments showed straightforwardly the tract described by Ramón y Cajal, which he had lost at midcourse because it diverges into the mesodiencephalic alar plate. Moreover, it was observed to bifurcate as it enters the diencephalon into a deep medial component not distinguished by Ramón y Cajal, which targets diencephalic and mesencephalic preoculomotor cell populations and the deep ZI and Forel’s field, and a thicker outer component, the part he described, which ascends through intermediate thalamic and pretectal alar structures (PIL, RETh, JcRt, CoRt) until it ends densely on the paratectal bed nucleus of the brachium of the superior colliculus (BSC). The latter is frequently misinterpreted as a lateral part of the SC. Other midbrain targets included the rubral area, the MRt, a novel bilateral reticular endorubral field (ERF), and the preisthmic cuneiform nucleus (Cnf).

    Keywords: Forebrain tracts, pyramidal collaterals, motor pathway, preoculomotor nuclei, zona incerta, posterior intralaminar nucleus, superior colliculus, BSC nucleus

    Received: 22 Sep 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Puelles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Luis Puelles, Departamento de Ciencias Morfológicas y Psicobiolo, University of Murcia, Murcia, 30100, Spain

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