AUTHOR=Di Pierdomenico Johnny , Gallego-Ortega Alejandro , Norte-Muñoz María , Vidal-Villegas Beatriz , Bravo Isaac , Boluda-Ruiz María , Bernal-Garro Jose Manuel , Fernandez-Bueno Iván , Pastor-Jimeno Jose Carlos , Villegas-Pérez María Paz , Avilés-Trigueros Marcelino , de los Ríos Cristobal , Vidal-Sanz Manuel 

TITLE=Evaluation of the neuroprotective efficacy of the gramine derivative ITH12657 against NMDA-induced excitotoxicity in the rat retina

JOURNAL=Frontiers in Neuroanatomy

VOLUME=Volume 18 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2024.1335176

DOI=10.3389/fnana.2024.1335176

ISSN=1662-5129

ABSTRACT=• Administration of 10 mg/kg ITH12657, starting 12 hours before NMDA injection and dispensed for 3 days, resulted in the best significant protection of Brn3a+RGCs against NMDA-induced excitotoxicity • ITH12657-treatment showed a significant preservation of retinal thickness when compared to vehicle-treament• Treatment with ITH12657 resulted, in smaller reductions of pSTR and b-wave amplitudes compared to those treated with vehicle, indicating that ITH12657 treatment offered functional protection against NMDA-induced retinal excitotoxicity • ITH12657 afforded a significant protection against NMDA-induced excitotoxicity for the populations of Brn3a+RGC, αRGC, and αONs-RGC, but not for the population of αOFF-RGC