AUTHOR=Wang Yang , Liu Zhixiang , Sun Da , Sun Leqiang , Cao Gang , Dai Jinxia TITLE=The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis JOURNAL=Frontiers in Neuroanatomy VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2022.886925 DOI=10.3389/fnana.2022.886925 ISSN=1662-5129 ABSTRACT=

The various brain functions rely on the intricate connection networks and certain molecular characteristics of neurons in the brain. However, the databases for the mouse brain connectome and chemo-connectome are still inadequate, hindering the brain circuital and functional analysis. Here, we created mice brain connectome and chemo-connectome databases based on mouse brain projection data of 295 non-overlapping brain areas and in situ hybridization (ISH) data of 50 representative neurotransmission-related genes from the Allen Brain Institute. Based on this connectome and chemo-connectome databases, functional connection patterns and detailed chemo-connectome for monoaminergic nuclei were analyzed and visualized. These databases will aid in the comprehensive research of the mouse connectome and chemo-connectome in the whole brain and serve as a convenient resource for systematic analysis of the brain connection and function.