AUTHOR=Piszár Ildikó , Lőrincz Magor L. 

TITLE=Differential Serotonergic Modulation of Principal Neurons and Interneurons in the Anterior Piriform Cortex

JOURNAL=Frontiers in Neuroanatomy

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2022.821695

DOI=10.3389/fnana.2022.821695

ISSN=1662-5129

ABSTRACT=<p>Originating from the brainstem raphe nuclei, serotonin is an important neuromodulator involved in a variety of physiological and pathological functions. Specific optogenetic stimulation of serotonergic neurons results in the divisive suppression of spontaneous, but not sensory evoked activity in the majority of neurons in the primary olfactory cortex and an increase in firing in a minority of neurons. To reveal the mechanisms involved in this dual serotonergic control of cortical activity we used a combination of <italic>in vitro</italic> electrophysiological recordings from identified neurons in the primary olfactory cortex, optogenetics and pharmacology and found that serotonin suppressed the activity of principal neurons, but excited local interneurons. The results have important implications in sensory information processing and other functions of the olfactory cortex and related brain areas.</p>