AUTHOR=Lkhagvasuren Battuvshin , Mee-inta Onanong , Zhao Zi-Wei , Hiramoto Tetsuya , Boldbaatar Damdindorj , Kuo Yu-Min 

TITLE=Pancreas-Brain Crosstalk

JOURNAL=Frontiers in Neuroanatomy

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2021.691777

DOI=10.3389/fnana.2021.691777

ISSN=1662-5129

ABSTRACT=<p>The neural regulation of glucose homeostasis in normal and challenged conditions involves the modulation of pancreatic islet-cell function. Compromising the pancreas innervation causes islet autoimmunity in type 1 diabetes and islet cell dysfunction in type 2 diabetes. However, despite the richly innervated nature of the pancreas, islet innervation remains ill-defined. Here, we review the neuroanatomical and humoral basis of the cross-talk between the endocrine pancreas and autonomic and sensory neurons. Identifying the neurocircuitry and neurochemistry of the neuro-insular network would provide clues to neuromodulation-based approaches for the prevention and treatment of diabetes and obesity.</p>