AUTHOR=Boije Henrik , Shirazi Fard Shahrzad , Edqvist Per-Henrik , Hallböök Finn 

TITLE=Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease

JOURNAL=Frontiers in Neuroanatomy

VOLUME=10

YEAR=2016

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2016.00077

DOI=10.3389/fnana.2016.00077

ISSN=1662-5129

ABSTRACT=<p>Thorough investigation of a neuronal population can help reveal key aspects regarding the nervous system and its development. The retinal horizontal cells have several extraordinary features making them particularly interesting for addressing questions regarding fate assignment and subtype specification. In this review we discuss and summarize data concerning the formation and diversity of horizontal cells, how morphology is correlated to molecular markers, and how fate assignment separates the horizontal lineage from the lineages of other retinal cell types. We discuss the novel and unique features of the final cell cycle of horizontal cell progenitors and how they may relate to retinoblastoma carcinogenesis.</p>