AUTHOR=Cebrián Carolina , Loike John D. , Sulzer David 

TITLE=Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases

JOURNAL=Frontiers in Neuroanatomy

VOLUME=8

YEAR=2014

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2014.00114

DOI=10.3389/fnana.2014.00114

ISSN=1662-5129

ABSTRACT=<p>Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in developmental synaptic plasticity and axonal regeneration in the central nervous system (CNS), but recent findings demonstrate that constitutive neuronal MHC-I can also be involved in neurodegenerative diseases by playing a neuroinflammtory role. Recent reports demonstrate its expression <italic>in vitro</italic> and in human postmortem samples and support a role in neurodegeneration involving proinflammatory cytokines, activated microglia and increased cytosolic oxidative stress. Major histocompatibility complex I may be important for both normal development and pathogenesis of some CNS diseases including Parkinson’s.</p>