AUTHOR=Brown Angus M. , Hamann Martine 

TITLE=Computational modeling of the effects of auditory nerve dysmyelination

JOURNAL=Frontiers in Neuroanatomy

VOLUME=8

YEAR=2014

URL=https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2014.00073

DOI=10.3389/fnana.2014.00073

ISSN=1662-5129

ABSTRACT=<p>Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na<sup>+</sup>, Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na<sup>+</sup> channel density (rather than the redistribution of voltage gated Na<sup>+</sup>, Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE).</p>