The final, formatted version of the article will be published soon.
BRIEF RESEARCH REPORT article
Front. Neural Circuits
Volume 19 - 2025 |
doi: 10.3389/fncir.2025.1533791
This article is part of the Research Topic Neurodevelopmental Origins of Resilience Across Species and Life Course View all 7 articles
Early-life stress differentially affects CA3 synaptic inputs converging on apical and basal dendrites of CA1 pyramidal neurons
Provisionally accepted- 1 Pirogov Russian National Research Medical University, Moscow, Moscow Oblast, Russia
- 2 Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Nizhny Novgorod Oblast, Russia
- 3 Institute of Higher Nervous Activity and Neurophysiology (RAS), Moscow, Moscow Oblast, Russia
- 4 Kazan Federal University, Kazan, Tatarstan, Russia
There is evidence that stress factors and negative experiences in early in life may affect brain development leading to mental disorders in adulthood (Heim and Nemeroff, 2002). At the early stage of postnatal ontogenesis, the central nervous system has high plasticity, which decreases with maturation. Most likely, this high plasticity is necessary for establishing synaptic connections between different types of neurons, regulating the strength of individual synapses, and ultimately forming properly functioning neuronal networks. The vast majority of studies have examined the effects of early-life stress (ELS) on gene expression or behavior and memory.However, the impact of ELS on functional synaptic development and on the plastic properties of excitatory and inhibitory synapses are currently much less understood.Based on data obtained in a few studies it has been suggested that ELS reduces longterm potentiation (LTP) at Schaffer collateral to CA1 pyramidal cell synapses in adulthood. Nevertheless, different groups have reported somewhat contradictory results. In this report we show that ELS differentially affects LTP at CA3 to CA1 pyramidal cell inputs, at synapses on apical dendrites LTP is reduced, while LTP at synapses formed by CA3 pyramidal cells on basal dendrites remains unaffected.
Keywords: early life stress, LTP, Hippocampus, excitation, CA1 pyramidal cell
Received: 24 Nov 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 Jappy, Sokolov, Dobryakova, Krut’, Maltseva, Fedulina, Smirnov and Rozov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Andrei Rozov, Kazan Federal University, Kazan, 420008, Tatarstan, Russia
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.