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REVIEW article

Front. Neural Circuits
Volume 18 - 2024 | doi: 10.3389/fncir.2024.1504422
This article is part of the Research Topic Inducing Lifelong Plasticity (iPlasticity) by Brain Rejuvenation: Elucidation and Manipulation of Critical Period Mechanisms View all 4 articles

The neuronal Golgi in neural circuit formation and reorganization

Provisionally accepted
Naoki Nakagawa Naoki Nakagawa *
  • National Institute of Genetics (Japan), Mishima, Japan

The final, formatted version of the article will be published soon.

    The Golgi apparatus is a central hub in the intracellular secretory pathway. By positioning in the specific intracellular region and transporting materials to spatially restricted compartments, the Golgi apparatus contributes to the cell polarity establishment and morphological specification in diverse cell types. In neurons, the Golgi apparatus mediates several essential steps of initial neural circuit formation during early brain development, such as axon-dendrite polarization, neuronal migration, primary dendrite specification, and dendritic arbor elaboration. Moreover, neuronal activity-dependent remodeling of the Golgi structure enables morphological changes in neurons, which provides the cellular basis of circuit reorganization during postnatal critical period. In this review, I summarize recent findings illustrating the unique Golgi positioning and its developmental dynamics in various types of neurons. I also discuss the upstream regulators for the Golgi positioning in neurons, and functional roles of the Golgi in neural circuit formation and reorganization. Elucidating how Golgi apparatus sculpts neuronal connectivity would deepen our understanding of the 2 cellular/molecular basis of neural circuit development and plasticity.

    Keywords: Brain Development, neuronal maturation, Neural circuit formation, Neural circuit reorganization, Golgi Apparatus, Dendrite

    Received: 30 Sep 2024; Accepted: 20 Nov 2024.

    Copyright: © 2024 Nakagawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Naoki Nakagawa, National Institute of Genetics (Japan), Mishima, Japan

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