AUTHOR=Wong Kelly L. L. , Nair Aditya , Augustine George J. 

TITLE=Changing the Cortical Conductor’s Tempo: Neuromodulation of the Claustrum

JOURNAL=Frontiers in Neural Circuits

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2021.658228

DOI=10.3389/fncir.2021.658228

ISSN=1662-5110

ABSTRACT=<p>The claustrum is a thin sheet of neurons that is densely connected to many cortical regions and has been implicated in numerous high-order brain functions. Such brain functions arise from brain states that are influenced by neuromodulatory pathways from the cholinergic basal forebrain, dopaminergic substantia nigra and ventral tegmental area, and serotonergic raphe. Recent revelations that the claustrum receives dense input from these structures have inspired investigation of state-dependent control of the claustrum. Here, we review neuromodulation in the claustrum—from anatomical connectivity to behavioral manipulations—to inform future analyses of claustral function.</p>