AUTHOR=Cox Jane A. , Voigt Mark M. 

TITLE=The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain

JOURNAL=Frontiers in Neural Circuits

VOLUME=13

YEAR=2019

URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2019.00014

DOI=10.3389/fncir.2019.00014

ISSN=1662-5110

ABSTRACT=<p>Little is known about the molecular and cellular mechanisms involved in the formation of the cranial peripheral sensory system in vertebrates. To identify genes involved in the formation of these circuits, we performed a forward genetic screen utilizing a transgenic zebrafish line (<italic>p2rx3.2:gfp</italic><sup>sl1</sup>) that expresses green fluorescent protein (gfp) in sensory neurons of the Vth, VIIth, IXth and Xth cranial ganglia. Here, we describe a novel zebrafish mutant in which a missense mutation in the <italic>adam19b</italic> gene selectively affects the epibranchial sensory circuits.</p>