AUTHOR=Larsen Rylan S. , Waters Jack 

TITLE=Neuromodulatory Correlates of Pupil Dilation

JOURNAL=Frontiers in Neural Circuits

VOLUME=12

YEAR=2018

URL=https://www.frontiersin.org/journals/neural-circuits/articles/10.3389/fncir.2018.00021

DOI=10.3389/fncir.2018.00021

ISSN=1662-5110

ABSTRACT=<p>Pupillometry has long been used as a measure of brain state. Changes in pupil diameter are thought to coincide with the activity of neuromodulators, including noradrenaline and acetylcholine, producing alterations in the brain state and corresponding changes in behavior. Here we review mechanisms underlying the control of pupil diameter and how these mechanisms are correlated with changes in cortical activity and the recruitment of neuromodulatory circuits.</p>